Drug interactions
Amlodipine-perindopril + Ceritinib
Severity: Moderate
Amlodipine-perindopril and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may increase amlodipine concentrations. This can lead to more hypotension and peripheral edema, and ceritinib also slows the heart rate, which may add to cardiovascular effects.
What this interaction means in plain words
Amlodipine-perindopril and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Ceritinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ceritinib reduces amlodipine metabolism, with additive bradycardia and hypotension.
What to do
Monitor blood pressure, heart rate and edema when starting ceritinib. Reduce the amlodipine dose if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Ceritinib?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may increase amlodipine concentrations. This can lead to more hypotension and peripheral edema, and ceritinib also slows the heart rate, which may add to cardiovascular effects.
How serious is the interaction between Amlodipine-perindopril and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema when starting ceritinib. Reduce the amlodipine dose if hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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