Drug interactions
Amlodipine-perindopril + Digoxin
Severity: Moderate
Amlodipine-perindopril and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may modestly raise digoxin concentrations, mainly through reduced renal function, and amlodipine has little effect. Digoxin toxicity is possible, especially in elderly or renally impaired patients.
What this interaction means in plain words
Amlodipine-perindopril and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Changes in renal perfusion and digoxin renal clearance, with possible small changes in tubular secretion; mechanism not firmly established.
What to do
Monitor digoxin concentration, renal function and potassium when perindopril is started, and adjust the digoxin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Amlodipine-perindopril with Digoxin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may modestly raise digoxin concentrations, mainly through reduced renal function, and amlodipine has little effect. Digoxin toxicity is possible, especially in elderly or renally impaired patients.
How serious is the interaction between Amlodipine-perindopril and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration, renal function and potassium when perindopril is started, and adjust the digoxin dose as needed.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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