Drug interactions
Amlodipine-perindopril + Entecavir
Severity: Minor
Amlodipine-perindopril and Entecavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated mainly by the kidney through filtration and tubular secretion. Perindopril may affect renal function, and either drug could accumulate if kidney function declines. A clinically meaningful pharmacokinetic interaction is not well documented.
What this interaction means in plain words
Amlodipine-perindopril and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Entecavir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion or reduced renal clearance if ACE inhibitor lowers glomerular filtration.
What to do
Monitor serum creatinine and adjust entecavir dose according to creatinine clearance if renal function changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Entecavir
Frequently asked questions
Can I take Amlodipine-perindopril with Entecavir?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated mainly by the kidney through filtration and tubular secretion. Perindopril may affect renal function, and either drug could accumulate if kidney function declines. A clinically meaningful pharmacokinetic interaction is not well documented.
How serious is the interaction between Amlodipine-perindopril and Entecavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and adjust entecavir dose according to creatinine clearance if renal function changes.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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