Drug interactions
Amlodipine-perindopril + Erythromycin lactobionate
Severity: Moderate
Amlodipine-perindopril and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and may raise amlodipine levels. Hypotension and, in older adults, adverse outcomes such as shock or acute kidney injury have been described with CYP3A4-inhibiting macrolides and calcium channel blockers.
What this interaction means in plain words
Amlodipine-perindopril and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by erythromycin.
What to do
Monitor blood pressure during the antibiotic course, especially in elderly patients. Consider an alternative macrolide such as azithromycin, or reduce the amlodipine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin inhibits CYP3A4 and may raise amlodipine levels. Hypotension and, in older adults, adverse outcomes such as shock or acute kidney injury have been described with CYP3A4-inhibiting macrolides and calcium channel blockers.
How serious is the interaction between Amlodipine-perindopril and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during the antibiotic course, especially in elderly patients. Consider an alternative macrolide such as azithromycin, or reduce the amlodipine dose.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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