Drug interactions
Amlodipine-perindopril + Finerenone
Severity: Major
Amlodipine-perindopril and Finerenone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perindopril and finerenone both raise serum potassium, so hyperkalemia risk is increased, especially with renal impairment. Amlodipine is a weak CYP3A4 inhibitor and may modestly increase finerenone exposure, adding to the effect.
What this interaction means in plain words
Amlodipine-perindopril and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-perindopril belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Additive potassium retention through ACE inhibition and mineralocorticoid receptor antagonism, plus weak CYP3A4 inhibition by amlodipine raising finerenone levels.
What to do
Check serum potassium and renal function before starting and during the first weeks, then periodically. Adjust or withhold finerenone according to its labeled potassium thresholds.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Finerenone?
MediHelp rates the interaction as major. Amlodipine-perindopril and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Perindopril and finerenone both raise serum potassium, so hyperkalemia risk is increased, especially with renal impairment. Amlodipine is a weak CYP3A4 inhibitor and may modestly increase finerenone exposure, adding to the effect.
How serious is the interaction between Amlodipine-perindopril and Finerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function before starting and during the first weeks, then periodically. Adjust or withhold finerenone according to its labeled potassium thresholds.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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