Drug interactions
Amlodipine-perindopril + Melatonin
Severity: Minor
Amlodipine-perindopril and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has been reported to raise blood pressure in some patients taking dihydropyridine calcium channel blockers, potentially reducing the antihypertensive effect of amlodipine. The evidence is limited.
What this interaction means in plain words
Amlodipine-perindopril and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Mechanism is not well established; melatonin may have vasoactive effects that oppose calcium channel blockade.
What to do
Monitor blood pressure if melatonin is used regularly. Adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Amlodipine-perindopril with Melatonin?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has been reported to raise blood pressure in some patients taking dihydropyridine calcium channel blockers, potentially reducing the antihypertensive effect of amlodipine. The evidence is limited.
How serious is the interaction between Amlodipine-perindopril and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if melatonin is used regularly. Adjust antihypertensive therapy if control worsens.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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