Drug interactions
Amlodipine-perindopril + Pregabalin
Severity: Moderate
Amlodipine-perindopril and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angioedema of the face, lips and airway has been reported with pregabalin and is a recognized adverse effect of ACE inhibitors. Using both may add to the risk of this potentially airway-threatening reaction.
What this interaction means in plain words
Amlodipine-perindopril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Pregabalin belongs to Central Nervous System.
Why it happens
Additive risk of angioedema through different mechanisms; ACE inhibitors raise bradykinin, while the mechanism for pregabalin is not established.
What to do
Counsel the patient to stop both drugs and seek urgent care if swelling of the face, tongue or throat occurs. Review the combination in anyone with prior angioedema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Amlodipine-perindopril with Pregabalin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angioedema of the face, lips and airway has been reported with pregabalin and is a recognized adverse effect of ACE inhibitors. Using both may add to the risk of this potentially airway-threatening reaction.
How serious is the interaction between Amlodipine-perindopril and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to stop both drugs and seek urgent care if swelling of the face, tongue or throat occurs. Review the combination in anyone with prior angioedema.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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