Drug interactions
Amlodipine-perindopril + Rucaparib
Severity: Minor
Amlodipine-perindopril and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may slightly increase amlodipine exposure. Clinical consequences are likely small but could include mild hypotension or edema.
What this interaction means in plain words
Amlodipine-perindopril and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Rucaparib weakly inhibits CYP3A4, reducing amlodipine metabolism.
What to do
Monitor blood pressure and ankle edema after rucaparib is started. Reduce the amlodipine dose only if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Amlodipine-perindopril with Rucaparib?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may slightly increase amlodipine exposure. Clinical consequences are likely small but could include mild hypotension or edema.
How serious is the interaction between Amlodipine-perindopril and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ankle edema after rucaparib is started. Reduce the amlodipine dose only if adverse effects appear.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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