Drug interactions
Amlodipine-perindopril + Stiripentol
Severity: Moderate
Amlodipine-perindopril and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so amlodipine exposure may change unpredictably. This could cause hypotension or loss of blood pressure control.
What this interaction means in plain words
Amlodipine-perindopril and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits and induces CYP3A4, altering amlodipine metabolism.
What to do
Monitor blood pressure and edema when stiripentol is started or changed. Adjust the amlodipine dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Amlodipine-perindopril with Stiripentol?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so amlodipine exposure may change unpredictably. This could cause hypotension or loss of blood pressure control.
How serious is the interaction between Amlodipine-perindopril and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when stiripentol is started or changed. Adjust the amlodipine dose according to response.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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