Drug interactions
Amlodipine-perindopril + Temsirolimus
Severity: Major
Amlodipine-perindopril and Temsirolimus: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ACE inhibitor or calcium channel blocker with an mTOR inhibitor such as temsirolimus is associated with increased angioedema risk. Angioedema may affect the airway and can be serious.
What this interaction means in plain words
Amlodipine-perindopril and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-perindopril belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Additive impairment of bradykinin degradation by ACE inhibition and mTOR inhibition; calcium channel blockers may contribute through an unclear mechanism.
What to do
Counsel patients to report facial or throat swelling immediately and consider a different antihypertensive class. Stop perindopril if angioedema occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Temsirolimus?
MediHelp rates the interaction as major. Amlodipine-perindopril and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ACE inhibitor or calcium channel blocker with an mTOR inhibitor such as temsirolimus is associated with increased angioedema risk. Angioedema may affect the airway and can be serious.
How serious is the interaction between Amlodipine-perindopril and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report facial or throat swelling immediately and consider a different antihypertensive class. Stop perindopril if angioedema occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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