Drug interactions
Apalutamide + Avanafil
Severity: Moderate
Apalutamide and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and is expected to markedly lower avanafil concentrations, causing loss of erectile efficacy.
What this interaction means in plain words
Apalutamide and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Avanafil belongs to Genitourinary.
Why it happens
Induction of CYP3A4 increasing avanafil metabolism.
What to do
Avoid the combination and choose an alternative erectile dysfunction treatment less dependent on CYP3A4. Do not raise the avanafil dose above the labeled maximum.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Avanafil?
MediHelp rates the interaction as moderate. Apalutamide and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and is expected to markedly lower avanafil concentrations, causing loss of erectile efficacy.
How serious is the interaction between Apalutamide and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative erectile dysfunction treatment less dependent on CYP3A4. Do not raise the avanafil dose above the labeled maximum.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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