Drug interactions
Apalutamide + Calcifediol
Severity: Minor
Apalutamide and Calcifediol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may accelerate the breakdown of calcifediol, potentially lowering active vitamin D levels. The clinical effect is usually modest and shows up as reduced control of vitamin D status or secondary hyperparathyroidism.
What this interaction means in plain words
Apalutamide and Calcifediol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Calcifediol belongs to Musculoskeletal.
Why it happens
Induction of CYP enzymes, including CYP3A4, may increase the catabolism of calcifediol.
What to do
Monitor serum 25-hydroxyvitamin D, calcium and PTH, and adjust the calcifediol dose if levels fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Apalutamide with Calcifediol?
MediHelp rates the interaction as minor. Apalutamide and Calcifediol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide may accelerate the breakdown of calcifediol, potentially lowering active vitamin D levels. The clinical effect is usually modest and shows up as reduced control of vitamin D status or secondary hyperparathyroidism.
How serious is the interaction between Apalutamide and Calcifediol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum 25-hydroxyvitamin D, calcium and PTH, and adjust the calcifediol dose if levels fall.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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