Drug interactions
Apalutamide + Disopyramide
Severity: Moderate
Apalutamide and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower disopyramide concentrations, risking loss of antiarrhythmic control. Metabolism to the less active mono-N-dealkylated metabolite may increase.
What this interaction means in plain words
Apalutamide and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Disopyramide belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 increases disopyramide metabolism.
What to do
Monitor ECG and arrhythmia control, and adjust the disopyramide dose, using serum levels if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Apalutamide with Disopyramide?
MediHelp rates the interaction as moderate. Apalutamide and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may lower disopyramide concentrations, risking loss of antiarrhythmic control. Metabolism to the less active mono-N-dealkylated metabolite may increase.
How serious is the interaction between Apalutamide and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and arrhythmia control, and adjust the disopyramide dose, using serum levels if available.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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