Drug interactions
Apalutamide + Elagolix
Severity: Moderate
Apalutamide and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a CYP3A4 inducer and elagolix is a CYP3A4 substrate, so elagolix exposure and efficacy may be reduced. Elagolix is itself a weak-to-moderate CYP3A4 inducer, but this is unlikely to affect apalutamide in a meaningful way. The combination has little data.
What this interaction means in plain words
Apalutamide and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Elagolix belongs to Musculoskeletal.
Why it happens
Apalutamide induces CYP3A4, increasing the metabolism of elagolix.
What to do
Monitor for loss of symptom control with elagolix. Consider an alternative therapy if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Apalutamide with Elagolix?
MediHelp rates the interaction as moderate. Apalutamide and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a CYP3A4 inducer and elagolix is a CYP3A4 substrate, so elagolix exposure and efficacy may be reduced. Elagolix is itself a weak-to-moderate CYP3A4 inducer, but this is unlikely to affect apalutamide in a meaningful way. The combination has little data.
How serious is the interaction between Apalutamide and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control with elagolix. Consider an alternative therapy if response is inadequate.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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