Drug interactions
Apalutamide + Enfortumab vedotin
Severity: Minor
Apalutamide and Enfortumab vedotin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic component of enfortumab vedotin, MMAE, is metabolized by CYP3A4. A CYP3A4 inducer like apalutamide could reduce unconjugated MMAE exposure, but this would be expected to have a limited effect on efficacy.
What this interaction means in plain words
Apalutamide and Enfortumab vedotin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Enfortumab vedotin belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4, which may increase the clearance of unconjugated MMAE.
What to do
No dose adjustment is recommended. Monitor tumor response as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
Frequently asked questions
Can I take Apalutamide with Enfortumab vedotin?
MediHelp rates the interaction as minor. Apalutamide and Enfortumab vedotin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The cytotoxic component of enfortumab vedotin, MMAE, is metabolized by CYP3A4. A CYP3A4 inducer like apalutamide could reduce unconjugated MMAE exposure, but this would be expected to have a limited effect on efficacy.
How serious is the interaction between Apalutamide and Enfortumab vedotin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is recommended. Monitor tumor response as usual.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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