Drug interactions
Apalutamide + Posaconazole
Severity: Moderate
Apalutamide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase apalutamide exposure. Apalutamide itself is a CYP3A4 inducer and can lower posaconazole levels, so the net effect is uncertain.
What this interaction means in plain words
Apalutamide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of apalutamide, while apalutamide induces enzymes and transporters that reduce posaconazole exposure.
What to do
Monitor for apalutamide adverse effects such as rash and fatigue, and consider reducing its dose if poorly tolerated. Check posaconazole trough levels to ensure efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Posaconazole?
MediHelp rates the interaction as moderate. Apalutamide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase apalutamide exposure. Apalutamide itself is a CYP3A4 inducer and can lower posaconazole levels, so the net effect is uncertain.
How serious is the interaction between Apalutamide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for apalutamide adverse effects such as rash and fatigue, and consider reducing its dose if poorly tolerated. Check posaconazole trough levels to ensure efficacy.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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