Drug interactions
Apalutamide + Propofol
Severity: Minor
Apalutamide and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces drug-metabolizing enzymes and may lower exposure to substrates of several pathways. Propofol is cleared mainly by hepatic glucuronidation and CYP2B6 and CYP2C9, and has a short, titrated effect, so a clinically important reduction in effect is unlikely.
What this interaction means in plain words
Apalutamide and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Propofol belongs to Central Nervous System.
Why it happens
Enzyme induction by apalutamide could modestly increase propofol metabolism.
What to do
No dose change is needed in advance; titrate propofol to clinical effect and anesthetic depth monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Propofol?
MediHelp rates the interaction as minor. Apalutamide and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide induces drug-metabolizing enzymes and may lower exposure to substrates of several pathways. Propofol is cleared mainly by hepatic glucuronidation and CYP2B6 and CYP2C9, and has a short, titrated effect, so a clinically important reduction in effect is unlikely.
How serious is the interaction between Apalutamide and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed in advance; titrate propofol to clinical effect and anesthetic depth monitoring.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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