Drug interactions
Apalutamide + Ticlopidine
Severity: Moderate
Apalutamide and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 and CYP2C19 inducer and may lower ticlopidine exposure, which could reduce its antiplatelet effect. Since ticlopidine is metabolized by several enzymes, the effect is uncertain.
What this interaction means in plain words
Apalutamide and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Ticlopidine belongs to Cardiovascular.
Why it happens
Induction of hepatic CYP enzymes by apalutamide increases ticlopidine clearance.
What to do
Consider an alternative antiplatelet agent. If used together, monitor for loss of antiplatelet efficacy and thrombotic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Ticlopidine?
MediHelp rates the interaction as moderate. Apalutamide and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 and CYP2C19 inducer and may lower ticlopidine exposure, which could reduce its antiplatelet effect. Since ticlopidine is metabolized by several enzymes, the effect is uncertain.
How serious is the interaction between Apalutamide and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiplatelet agent. If used together, monitor for loss of antiplatelet efficacy and thrombotic events.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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