Drug interactions
Apomorphine + Leuprolide
Severity: Moderate
Apomorphine and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide may prolong the QT interval through androgen deprivation, and apomorphine has also been associated with QT prolongation. Combined use may increase the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Apomorphine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Leuprolide belongs to Endocrine.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects.
What to do
Obtain a baseline ECG and monitor periodically, correcting potassium and magnesium. Avoid other QT-prolonging drugs and reassess if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Leuprolide?
MediHelp rates the interaction as moderate. Apomorphine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leuprolide may prolong the QT interval through androgen deprivation, and apomorphine has also been associated with QT prolongation. Combined use may increase the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Apomorphine and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor periodically, correcting potassium and magnesium. Avoid other QT-prolonging drugs and reassess if QTc lengthens.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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