Drug interactions
Apomorphine + Prochlorperazine
Severity: Major
Apomorphine and Prochlorperazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine blocks dopamine D2 receptors and directly opposes the dopaminergic effect of apomorphine, which may worsen Parkinson disease symptoms. Additive hypotension and sedation may also occur.
What this interaction means in plain words
Apomorphine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apomorphine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Central dopamine D2 antagonism counteracts apomorphine agonist activity.
What to do
Avoid prochlorperazine in patients treated with apomorphine; use an antiemetic without dopamine-blocking activity, such as ondansetron or domperidone where available, noting that ondansetron is contraindicated with apomorphine in labeling in some regions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Prochlorperazine?
MediHelp rates the interaction as major. Apomorphine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prochlorperazine blocks dopamine D2 receptors and directly opposes the dopaminergic effect of apomorphine, which may worsen Parkinson disease symptoms. Additive hypotension and sedation may also occur.
How serious is the interaction between Apomorphine and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prochlorperazine in patients treated with apomorphine; use an antiemetic without dopamine-blocking activity, such as ondansetron or domperidone where available, noting that ondansetron is contraindicated with apomorphine in labeling in some regions.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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