Drug interactions
Aprepitant + Avanafil
Severity: Moderate
Aprepitant and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is cleared mainly by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Avanafil exposure may increase, raising the risk of hypotension, headache, flushing and priapism.
What this interaction means in plain words
Aprepitant and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Avanafil belongs to Genitourinary.
Why it happens
Aprepitant inhibits CYP3A4, reducing avanafil clearance.
What to do
Limit avanafil to a maximum of 50 mg no more than once every 24 hours during aprepitant use. Counsel on hypotension and prolonged erection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Aprepitant with Avanafil?
MediHelp rates the interaction as moderate. Aprepitant and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is cleared mainly by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Avanafil exposure may increase, raising the risk of hypotension, headache, flushing and priapism.
How serious is the interaction between Aprepitant and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit avanafil to a maximum of 50 mg no more than once every 24 hours during aprepitant use. Counsel on hypotension and prolonged erection.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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