Drug interactions
Aprepitant + Disopyramide
Severity: Moderate
Aprepitant and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is metabolized by CYP3A4, and aprepitant may increase its concentrations. Because disopyramide has a narrow therapeutic index, this could increase anticholinergic effects and QT prolongation or proarrhythmia.
What this interaction means in plain words
Aprepitant and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Disopyramide belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 by aprepitant reduces disopyramide clearance.
What to do
Monitor ECG (QT interval) and anticholinergic effects, and consider disopyramide serum levels. Reduce the dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Aprepitant with Disopyramide?
MediHelp rates the interaction as moderate. Aprepitant and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide is metabolized by CYP3A4, and aprepitant may increase its concentrations. Because disopyramide has a narrow therapeutic index, this could increase anticholinergic effects and QT prolongation or proarrhythmia.
How serious is the interaction between Aprepitant and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QT interval) and anticholinergic effects, and consider disopyramide serum levels. Reduce the dose if toxicity appears.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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