Drug interactions
Aprepitant + Maraviroc
Severity: Moderate
Aprepitant and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate, and moderate inhibitors can increase its exposure. The effect with short aprepitant courses is expected to be modest but may increase postural hypotension and other adverse effects.
What this interaction means in plain words
Aprepitant and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Maraviroc belongs to Anti Virals.
Why it happens
Aprepitant inhibits CYP3A4, reducing maraviroc clearance.
What to do
Monitor for orthostasis and maraviroc adverse effects. Dose adjustment depends on concomitant antiretrovirals, so follow maraviroc labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Aprepitant with Maraviroc?
MediHelp rates the interaction as moderate. Aprepitant and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 substrate, and moderate inhibitors can increase its exposure. The effect with short aprepitant courses is expected to be modest but may increase postural hypotension and other adverse effects.
How serious is the interaction between Aprepitant and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostasis and maraviroc adverse effects. Dose adjustment depends on concomitant antiretrovirals, so follow maraviroc labeling.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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