Drug interactions
Aprepitant + Posaconazole
Severity: Moderate
Aprepitant and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and can markedly raise aprepitant concentrations. This may increase aprepitant adverse effects such as fatigue, dizziness and elevated liver enzymes.
What this interaction means in plain words
Aprepitant and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole strongly inhibits CYP3A4, reducing aprepitant clearance.
What to do
Monitor for aprepitant adverse effects and liver tests; no routine dose change, but consider limiting aprepitant to the shortest regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Aprepitant with Posaconazole?
MediHelp rates the interaction as moderate. Aprepitant and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and can markedly raise aprepitant concentrations. This may increase aprepitant adverse effects such as fatigue, dizziness and elevated liver enzymes.
How serious is the interaction between Aprepitant and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects and liver tests; no routine dose change, but consider limiting aprepitant to the shortest regimen.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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