Drug interactions
Aprepitant + Ubrogepant
Severity: Moderate
Aprepitant and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor when given short term but can induce CYP3A4 with repeated dosing. Ubrogepant exposure could change in either direction, and the legacy direction is not well established. Lower exposure could reduce migraine relief, while higher exposure could increase adverse effects.
What this interaction means in plain words
Aprepitant and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Ubrogepant belongs to Central Nervous System.
Why it happens
Aprepitant has mixed CYP3A4 inhibitory and inducing effects that alter ubrogepant metabolism.
What to do
Use the lower ubrogepant dose recommended for moderate CYP3A4 inhibitors (50 mg initial dose, second dose 50 mg if needed) when aprepitant is being given. Monitor for efficacy and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Aprepitant with Ubrogepant?
MediHelp rates the interaction as moderate. Aprepitant and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor when given short term but can induce CYP3A4 with repeated dosing. Ubrogepant exposure could change in either direction, and the legacy direction is not well established. Lower exposure could reduce migraine relief, while higher exposure could increase adverse effects.
How serious is the interaction between Aprepitant and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lower ubrogepant dose recommended for moderate CYP3A4 inhibitors (50 mg initial dose, second dose 50 mg if needed) when aprepitant is being given. Monitor for efficacy and tolerability.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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