Drug interactions
Armodafinil + Disopyramide
Severity: Moderate
Armodafinil and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may lower disopyramide concentrations through enhanced metabolism, potentially reducing antiarrhythmic control.
What this interaction means in plain words
Armodafinil and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Disopyramide belongs to Cardiovascular.
Why it happens
Armodafinil induces CYP3A4, which converts disopyramide to its metabolite.
What to do
Monitor ECG and arrhythmia control, and check disopyramide levels if available; adjust dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Armodafinil with Disopyramide?
MediHelp rates the interaction as moderate. Armodafinil and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may lower disopyramide concentrations through enhanced metabolism, potentially reducing antiarrhythmic control.
How serious is the interaction between Armodafinil and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and arrhythmia control, and check disopyramide levels if available; adjust dose as needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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