Drug interactions
Armodafinil + Elagolix
Severity: Moderate
Armodafinil and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP3A4 inducers of weak to moderate strength, so each may lower the other's exposure. Reduced elagolix exposure could weaken its effect on endometriosis pain.
What this interaction means in plain words
Armodafinil and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Elagolix belongs to Musculoskeletal.
Why it happens
Mutual CYP3A4 induction increases metabolism of both drugs.
What to do
Monitor for reduced effect of either drug, particularly elagolix pain control and armodafinil wakefulness. Adjust doses if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Armodafinil with Elagolix?
MediHelp rates the interaction as moderate. Armodafinil and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CYP3A4 inducers of weak to moderate strength, so each may lower the other's exposure. Reduced elagolix exposure could weaken its effect on endometriosis pain.
How serious is the interaction between Armodafinil and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced effect of either drug, particularly elagolix pain control and armodafinil wakefulness. Adjust doses if response is inadequate.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
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