Drug interactions
Armodafinil + Enzalutamide
Severity: Moderate
Armodafinil and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer, so it is expected to lower armodafinil levels rather than raise them. Wakefulness benefit may diminish.
What this interaction means in plain words
Armodafinil and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, increasing the metabolism of armodafinil.
What to do
Monitor for reduced armodafinil effect and raise the dose if needed. Consider an alternative if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Armodafinil with Enzalutamide?
MediHelp rates the interaction as moderate. Armodafinil and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer, so it is expected to lower armodafinil levels rather than raise them. Wakefulness benefit may diminish.
How serious is the interaction between Armodafinil and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced armodafinil effect and raise the dose if needed. Consider an alternative if control is inadequate.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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