Drug interactions
Armodafinil + Lisdexamfetamine
Severity: Moderate
Armodafinil and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are wakefulness-promoting stimulants, so using them together can intensify insomnia, anxiety, nervousness, and increases in heart rate and blood pressure. The combination is uncommon and the added benefit is unproven.
What this interaction means in plain words
Armodafinil and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive CNS stimulant and sympathomimetic pharmacodynamic effects.
What to do
Monitor blood pressure, heart rate, sleep and anxiety symptoms. Reduce the dose of one agent if adverse stimulant effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Armodafinil and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are wakefulness-promoting stimulants, so using them together can intensify insomnia, anxiety, nervousness, and increases in heart rate and blood pressure. The combination is uncommon and the added benefit is unproven.
How serious is the interaction between Armodafinil and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, sleep and anxiety symptoms. Reduce the dose of one agent if adverse stimulant effects appear.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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