Drug interactions
Armodafinil + Maraviroc
Severity: Moderate
Armodafinil and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate and armodafinil is a weak to moderate CYP3A4 inducer. Maraviroc concentrations may fall, potentially reducing antiviral effect.
What this interaction means in plain words
Armodafinil and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Maraviroc belongs to Anti Virals.
Why it happens
Armodafinil induces CYP3A4, increasing the clearance of maraviroc.
What to do
Monitor HIV viral load and virologic response, and consider adjusting maraviroc dose according to the overall regimen. Avoid the combination if virologic control is uncertain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Armodafinil with Maraviroc?
MediHelp rates the interaction as moderate. Armodafinil and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 substrate and armodafinil is a weak to moderate CYP3A4 inducer. Maraviroc concentrations may fall, potentially reducing antiviral effect.
How serious is the interaction between Armodafinil and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and virologic response, and consider adjusting maraviroc dose according to the overall regimen. Avoid the combination if virologic control is uncertain.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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