Drug interactions
Armodafinil + Medroxyprogesterone
Severity: Moderate
Armodafinil and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak inducer of CYP3A4 and may lower exposure to medroxyprogesterone. With contraceptive use this could reduce efficacy and risk unintended pregnancy, and the effect can persist for a time after armodafinil is stopped.
What this interaction means in plain words
Armodafinil and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Medroxyprogesterone belongs to Endocrine.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of progestins.
What to do
Advise patients using hormonal contraception to add a barrier method during armodafinil therapy and for about one month after stopping. Consider a non-hormonal or non-CYP3A4-dependent contraceptive such as an intrauterine device.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Armodafinil with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Armodafinil and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak inducer of CYP3A4 and may lower exposure to medroxyprogesterone. With contraceptive use this could reduce efficacy and risk unintended pregnancy, and the effect can persist for a time after armodafinil is stopped.
How serious is the interaction between Armodafinil and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients using hormonal contraception to add a barrier method during armodafinil therapy and for about one month after stopping. Consider a non-hormonal or non-CYP3A4-dependent contraceptive such as an intrauterine device.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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