Drug interactions
Armodafinil + Montelukast
Severity: Minor
Armodafinil and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and could slightly lower montelukast levels. Montelukast relies mainly on CYP2C8, so the effect is unlikely to matter clinically.
What this interaction means in plain words
Armodafinil and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Montelukast belongs to Respiratory.
Why it happens
Weak induction of CYP3A4 by armodafinil increases the minor metabolic pathway of montelukast.
What to do
No adjustment is needed. Review symptom control if asthma or rhinitis worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Montelukast?
MediHelp rates the interaction as minor. Armodafinil and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and could slightly lower montelukast levels. Montelukast relies mainly on CYP2C8, so the effect is unlikely to matter clinically.
How serious is the interaction between Armodafinil and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Review symptom control if asthma or rhinitis worsens.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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