Drug interactions
Armodafinil + Posaconazole
Severity: Minor
Armodafinil and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase armodafinil exposure because armodafinil is partly metabolised by CYP3A4. This could increase adverse effects such as insomnia, anxiety, headache or tachycardia, though the effect is expected to be small.
What this interaction means in plain words
Armodafinil and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 reduces armodafinil clearance.
What to do
No routine dose change; monitor for increased stimulant or cardiovascular effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Posaconazole?
MediHelp rates the interaction as minor. Armodafinil and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may increase armodafinil exposure because armodafinil is partly metabolised by CYP3A4. This could increase adverse effects such as insomnia, anxiety, headache or tachycardia, though the effect is expected to be small.
How serious is the interaction between Armodafinil and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for increased stimulant or cardiovascular effects.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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