Drug interactions
Armodafinil + Riluzole
Severity: Minor
Armodafinil and Riluzole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riluzole is cleared mainly by CYP1A2. Armodafinil has been reported to cause weak CYP1A2 induction, so riluzole levels could fall slightly, although the clinical effect has not been established.
What this interaction means in plain words
Armodafinil and Riluzole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Riluzole belongs to Miscellaneous.
Why it happens
Possible weak CYP1A2 induction by armodafinil may increase riluzole metabolism.
What to do
No routine adjustment is needed. Be aware of possible reduced riluzole effect if armodafinil is added.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Frequently asked questions
Can I take Armodafinil with Riluzole?
MediHelp rates the interaction as minor. Armodafinil and Riluzole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Riluzole is cleared mainly by CYP1A2. Armodafinil has been reported to cause weak CYP1A2 induction, so riluzole levels could fall slightly, although the clinical effect has not been established.
How serious is the interaction between Armodafinil and Riluzole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Be aware of possible reduced riluzole effect if armodafinil is added.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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