Drug interactions
Armodafinil + Ubrogepant
Severity: Moderate
Armodafinil and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce ubrogepant exposure and its acute migraine efficacy.
What this interaction means in plain words
Armodafinil and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Ubrogepant belongs to Central Nervous System.
Why it happens
Armodafinil induces CYP3A4, increasing ubrogepant metabolism.
What to do
Use the labeled higher ubrogepant dose for CYP3A4 inducers (100 mg) and monitor migraine response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Armodafinil with Ubrogepant?
MediHelp rates the interaction as moderate. Armodafinil and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce ubrogepant exposure and its acute migraine efficacy.
How serious is the interaction between Armodafinil and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the labeled higher ubrogepant dose for CYP3A4 inducers (100 mg) and monitor migraine response.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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