Drug interactions
Avanafil + Bumetanide
Severity: Moderate
Avanafil and Bumetanide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil may add to the blood pressure lowering and volume-depleting effects of loop diuretics. This may lead to dizziness or symptomatic hypotension, especially in volume-depleted patients.
What this interaction means in plain words
Avanafil and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Bumetanide belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from PDE5-mediated vasodilation and diuretic-induced volume depletion.
What to do
Correct volume depletion before starting avanafil and use a low initial dose. Monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Bumetanide
Frequently asked questions
Can I take Avanafil with Bumetanide?
MediHelp rates the interaction as moderate. Avanafil and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil may add to the blood pressure lowering and volume-depleting effects of loop diuretics. This may lead to dizziness or symptomatic hypotension, especially in volume-depleted patients.
How serious is the interaction between Avanafil and Bumetanide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct volume depletion before starting avanafil and use a low initial dose. Monitor blood pressure and orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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