Drug interactions
Avanafil + Hydrochlorothiazide-irbesartan
Severity: Moderate
Avanafil and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor that causes vasodilation and modest blood pressure reduction. With irbesartan and hydrochlorothiazide it can produce additive hypotension, with dizziness or syncope.
What this interaction means in plain words
Avanafil and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive vasodilatory and blood pressure lowering effects.
What to do
Start avanafil at the lowest dose and ensure blood pressure is stable. Counsel the patient about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Avanafil and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor that causes vasodilation and modest blood pressure reduction. With irbesartan and hydrochlorothiazide it can produce additive hypotension, with dizziness or syncope.
How serious is the interaction between Avanafil and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start avanafil at the lowest dose and ensure blood pressure is stable. Counsel the patient about orthostatic symptoms.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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