Drug interactions
Avanafil + Metolazone
Severity: Moderate
Avanafil and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone can cause marked diuresis and volume depletion, and avanafil adds vasodilation. The combination may cause symptomatic hypotension.
What this interaction means in plain words
Avanafil and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Metolazone belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from vasodilation and diuretic-related volume reduction.
What to do
Assess volume status and blood pressure before starting avanafil and monitor for orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Metolazone
Frequently asked questions
Can I take Avanafil with Metolazone?
MediHelp rates the interaction as moderate. Avanafil and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone can cause marked diuresis and volume depletion, and avanafil adds vasodilation. The combination may cause symptomatic hypotension.
How serious is the interaction between Avanafil and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and blood pressure before starting avanafil and monitor for orthostatic symptoms.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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