Drug interactions
Avanafil + Stiripentol
Severity: Moderate
Avanafil and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can both inhibit and induce CYP3A4, so avanafil exposure may change unpredictably. This may cause either toxicity or reduced efficacy.
What this interaction means in plain words
Avanafil and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol alters avanafil metabolism.
What to do
Monitor avanafil response and tolerability after starting or stopping stiripentol, and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Avanafil with Stiripentol?
MediHelp rates the interaction as moderate. Avanafil and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can both inhibit and induce CYP3A4, so avanafil exposure may change unpredictably. This may cause either toxicity or reduced efficacy.
How serious is the interaction between Avanafil and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor avanafil response and tolerability after starting or stopping stiripentol, and adjust the dose accordingly.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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