Drug interactions
Brexpiprazole + Givosiran
Severity: Moderate
Brexpiprazole and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran has been shown to reduce CYP2D6 activity, which may raise brexpiprazole exposure. Higher levels can increase dose-related adverse effects such as akathisia, sedation and hypotension.
What this interaction means in plain words
Brexpiprazole and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Reduced CYP2D6 activity associated with givosiran, decreasing brexpiprazole clearance.
What to do
Monitor for brexpiprazole adverse effects and consider a dose reduction in line with labeling for CYP2D6 inhibition if tolerability problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Brexpiprazole with Givosiran?
MediHelp rates the interaction as moderate. Brexpiprazole and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran has been shown to reduce CYP2D6 activity, which may raise brexpiprazole exposure. Higher levels can increase dose-related adverse effects such as akathisia, sedation and hypotension.
How serious is the interaction between Brexpiprazole and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects and consider a dose reduction in line with labeling for CYP2D6 inhibition if tolerability problems occur.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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