Drug interactions
Brexpiprazole + Rolapitant
Severity: Moderate
Brexpiprazole and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole is cleared by CYP2D6 and CYP3A4, so inhibition of CYP2D6 raises its exposure. This may increase akathisia, sedation and metabolic or orthostatic effects.
What this interaction means in plain words
Brexpiprazole and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, decreasing brexpiprazole clearance.
What to do
Monitor for adverse effects and consider reducing the brexpiprazole dose, as labeling advises for strong CYP2D6 inhibitors. The effect persists at least 28 days after rolapitant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Rolapitant?
MediHelp rates the interaction as moderate. Brexpiprazole and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole is cleared by CYP2D6 and CYP3A4, so inhibition of CYP2D6 raises its exposure. This may increase akathisia, sedation and metabolic or orthostatic effects.
How serious is the interaction between Brexpiprazole and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and consider reducing the brexpiprazole dose, as labeling advises for strong CYP2D6 inhibitors. The effect persists at least 28 days after rolapitant.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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