Drug interactions
Bupropion + Solriamfetol
Severity: Moderate
Bupropion and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have noradrenergic and dopaminergic activity and can raise blood pressure and heart rate. Used together, the cardiovascular stimulation may be additive, which matters in patients with hypertension or cardiac disease.
What this interaction means in plain words
Bupropion and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect through inhibition of dopamine and norepinephrine reuptake by both agents.
What to do
Monitor blood pressure and heart rate at initiation and after dose changes. Reduce the dose or stop one agent if hypertension or tachycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Bupropion with Solriamfetol?
MediHelp rates the interaction as moderate. Bupropion and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have noradrenergic and dopaminergic activity and can raise blood pressure and heart rate. Used together, the cardiovascular stimulation may be additive, which matters in patients with hypertension or cardiac disease.
How serious is the interaction between Bupropion and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate at initiation and after dose changes. Reduce the dose or stop one agent if hypertension or tachycardia develops.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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