Drug interactions
Calcifediol + Digoxin
Severity: Moderate
Calcifediol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcifediol can raise serum calcium, and hypercalcemia sensitizes the myocardium to digoxin, increasing the risk of digitalis-related arrhythmias. The risk is greater with high vitamin D doses or renal impairment.
What this interaction means in plain words
Calcifediol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Digoxin belongs to Cardiovascular.
Why it happens
Vitamin D-induced hypercalcemia enhances digoxin's effect on myocardial excitability, increasing the chance of toxicity.
What to do
Check serum calcium periodically and keep it in the normal range. Monitor for digoxin toxicity and check digoxin levels if symptoms or ECG changes occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Digoxin?
MediHelp rates the interaction as moderate. Calcifediol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcifediol can raise serum calcium, and hypercalcemia sensitizes the myocardium to digoxin, increasing the risk of digitalis-related arrhythmias. The risk is greater with high vitamin D doses or renal impairment.
How serious is the interaction between Calcifediol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium periodically and keep it in the normal range. Monitor for digoxin toxicity and check digoxin levels if symptoms or ECG changes occur.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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