Drug interactions
Calcifediol + Hydrochlorothiazide
Severity: Moderate
Calcifediol and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, and calcifediol increases intestinal calcium absorption. Together they can raise serum calcium and in susceptible patients cause hypercalcemia, particularly with high vitamin D doses or renal impairment.
What this interaction means in plain words
Calcifediol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides enhance distal tubular calcium reabsorption while vitamin D metabolites increase gut calcium absorption, producing additive increases in serum calcium.
What to do
Monitor serum calcium (and renal function) at baseline and periodically, especially after dose changes. Reduce the vitamin D dose or stop the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcifediol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and calcifediol increases intestinal calcium absorption. Together they can raise serum calcium and in susceptible patients cause hypercalcemia, particularly with high vitamin D doses or renal impairment.
How serious is the interaction between Calcifediol and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium (and renal function) at baseline and periodically, especially after dose changes. Reduce the vitamin D dose or stop the thiazide if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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