Drug interactions
Calcifediol + Nevirapine
Severity: Minor
Calcifediol and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme inducers can speed the hydroxylation and clearance of vitamin D metabolites, lowering calcifediol activity. Over time this may contribute to reduced vitamin D status and bone effects.
What this interaction means in plain words
Calcifediol and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcifediol belongs to Musculoskeletal; Nevirapine belongs to Anti Virals.
Why it happens
Enzyme induction by nevirapine increases the catabolism of calcifediol.
What to do
Monitor serum 25-hydroxyvitamin D, calcium and PTH periodically. Adjust calcifediol dose if levels are low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Nevirapine?
MediHelp rates the interaction as minor. Calcifediol and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzyme inducers can speed the hydroxylation and clearance of vitamin D metabolites, lowering calcifediol activity. Over time this may contribute to reduced vitamin D status and bone effects.
How serious is the interaction between Calcifediol and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum 25-hydroxyvitamin D, calcium and PTH periodically. Adjust calcifediol dose if levels are low.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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