Drug interactions
Canagliflozin + Pentamidine
Severity: Moderate
Canagliflozin and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can cause hyperkalemia and renal toxicity, and also dysglycemia. Canagliflozin may modestly raise potassium, so combined use may worsen electrolyte and renal disturbances.
What this interaction means in plain words
Canagliflozin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive potassium-raising and renal effects; pentamidine also causes pancreatic beta-cell toxicity affecting glucose.
What to do
Monitor serum potassium, renal function and glucose during pentamidine therapy. Consider holding canagliflozin if acute kidney injury or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Canagliflozin with Pentamidine?
MediHelp rates the interaction as moderate. Canagliflozin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine can cause hyperkalemia and renal toxicity, and also dysglycemia. Canagliflozin may modestly raise potassium, so combined use may worsen electrolyte and renal disturbances.
How serious is the interaction between Canagliflozin and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and glucose during pentamidine therapy. Consider holding canagliflozin if acute kidney injury or volume depletion occurs.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
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