Drug interactions
Candesartan-hydrochlorothiazide + Empagliflozin
Severity: Moderate
Candesartan-hydrochlorothiazide and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has an osmotic diuretic effect, and combining it with a thiazide and an ARB increases the chance of volume depletion, hypotension and acute kidney injury. Risk is greater in older patients and those with reduced renal function.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Empagliflozin belongs to Endocrine.
Why it happens
Additive diuretic and natriuretic effects, together with ARB blunting of renal compensation, lead to intravascular volume depletion.
What to do
Assess volume status and renal function before starting empagliflozin and again during early therapy. Consider reducing the thiazide dose if volume depletion or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Empagliflozin?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has an osmotic diuretic effect, and combining it with a thiazide and an ARB increases the chance of volume depletion, hypotension and acute kidney injury. Risk is greater in older patients and those with reduced renal function.
How serious is the interaction between Candesartan-hydrochlorothiazide and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before starting empagliflozin and again during early therapy. Consider reducing the thiazide dose if volume depletion or hypotension develops.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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