Drug interactions
Captopril-hydrochlorothiazide + Empagliflozin
Severity: Moderate
Captopril-hydrochlorothiazide and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has an osmotic diuretic effect, which adds to the diuretic and ACE inhibitor effect and may cause volume depletion, hypotension and acute kidney injury. Older patients and those with renal impairment are at greater risk.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Empagliflozin belongs to Endocrine.
Why it happens
Additive natriuresis and volume depletion from SGLT2 inhibition and thiazide diuresis, with ACE inhibitor effect on renal hemodynamics.
What to do
Assess volume status before starting empagliflozin and consider reducing the diuretic dose; monitor blood pressure and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Empagliflozin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has an osmotic diuretic effect, which adds to the diuretic and ACE inhibitor effect and may cause volume depletion, hypotension and acute kidney injury. Older patients and those with renal impairment are at greater risk.
How serious is the interaction between Captopril-hydrochlorothiazide and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting empagliflozin and consider reducing the diuretic dose; monitor blood pressure and renal function.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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