Drug interactions
Cefpirome + Digoxin
Severity: Minor
Cefpirome and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral antibiotics can suppress Eubacterium lentum in the gut, which normally inactivates part of the digoxin dose. In a minority of patients this raises digoxin exposure. Cefpirome is available only as a parenteral agent, so the interaction is largely theoretical.
What this interaction means in plain words
Cefpirome and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpirome belongs to Anti Bacterial; Digoxin belongs to Cardiovascular.
Why it happens
Theoretical reduction of gut flora that metabolize digoxin, increasing its bioavailability; unlikely with a parenteral cephalosporin.
What to do
No routine action is needed; check digoxin levels and watch for toxicity symptoms if unexplained nausea or arrhythmia develops during antibiotic therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
Frequently asked questions
Can I take Cefpirome with Digoxin?
MediHelp rates the interaction as minor. Cefpirome and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral antibiotics can suppress Eubacterium lentum in the gut, which normally inactivates part of the digoxin dose. In a minority of patients this raises digoxin exposure. Cefpirome is available only as a parenteral agent, so the interaction is largely theoretical.
How serious is the interaction between Cefpirome and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check digoxin levels and watch for toxicity symptoms if unexplained nausea or arrhythmia develops during antibiotic therapy.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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