Drug interactions
Cefpirome + Estradiol
Severity: Minor
Cefpirome and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotic-related reduction of estrogen recycling by gut flora has been proposed to lower estradiol levels. Clinical evidence of reduced effect is weak.
What this interaction means in plain words
Cefpirome and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefpirome belongs to Anti Bacterial; Estradiol belongs to Endocrine.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogen through altered gut flora.
What to do
No action is generally needed; counsel patients to report breakthrough bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Cefpirome
- Amikacin + Cefpirome Moderate
- Bupropion-naltrexone + Cefpirome Moderate
- Bupropion + Cefpirome Moderate
- Cefpirome + Dexamethasone-tobramycin Moderate
- Cefpirome + Gentamicin Moderate
- Cefpirome + Streptomycin Moderate
Frequently asked questions
Can I take Cefpirome with Estradiol?
MediHelp rates the interaction as minor. Cefpirome and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotic-related reduction of estrogen recycling by gut flora has been proposed to lower estradiol levels. Clinical evidence of reduced effect is weak.
How serious is the interaction between Cefpirome and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; counsel patients to report breakthrough bleeding.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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